130 Toremifene Citrate Improves High-Density Lipoprotein Levels in Men on Testosterone Replacement Therapy The Journal of Sexual Medicine

It is used in advanced (metastatic) breast cancer and being evaluated for prevention of prostate cancer. Toremifene citrate is known to increase bone mineral density in prostate cancer patients undergoing androgen deprivation therapy?. In rodent models of fetal reproductive tract development, toremifene produced inhibition of uterine development in female pups similar to effects seen with diethylstilbestrol (DES) and tamoxifen.

• Toremifene causes a decrease in the estradiol-induced vaginal cornification index in some postmenopausal women, indicative of its antiestrogenic activity.
• Make sure your doctor knows if you had a heart rhythm problem, such as QT prolongation.
• In rats, toremifene causes regression of established dimethylbenzanthracene (DMBA)- induced mammary tumors.
• It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly.

The current competitive landscape for the target ER is characterized by the dominance of companies like Bayer AG, Pfizer Inc., and Mochida Pharmaceutical Co., Ltd. These companies have made significant progress in terms of drug development, with Bayer AG having the highest number of approved drugs. Indications such as contraception, osteoporosis (postmenopausal), and breast cancer have seen substantial advancements in drug development. Small molecule drugs and PROTACs are the drug types that are progressing most rapidly, indicating intense competition and innovation.

Vertigo, headache, and dizziness were observed in healthy volunteer studies at a daily dose of 680 mg for 5 days. The symptoms occurred in two of the five subjects during the third day of the treatment and disappeared within 2 days of discontinuation of the drug. No immediate concomitant changes in any measured clinical chemistry parameters were found. In a study in postmenopausal breast cancer patients, toremifene 400 mg/m2 /day caused dose-limiting nausea, vomiting, and dizziness, as well as reversible hallucinations and ataxia in one patient.

Pharmaceutical Insights: toremifene citrate’s R&D Progress and its Mechanism of Action on Drug Target

These effects are believed to be caused by toremifene and N-demethyltoremiifene. Toremifene had no effects on heart rate, PR and QRS interval duration [see BOX WARNING and WARNINGS AND PRECAUTIONS]. Adverse reactions reported during post approval use of FARESTON have been consistent with clinical trial experience. The most frequently reported adverse reactions related to FARESTON use since market introduction include hot flash, sweating, nausea, and vaginal discharge.

This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions. If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider.

ReviewToremifene for Breast Cancer: A Review of 20 Years of Data

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is pricing of Anabolic Steroids expired or no longer needed. Because of the possible risk to the infant, breastfeeding is not recommended while using this medication.

• No significant race-related differences in FARESTON effectiveness or safety were noted.
• If you become pregnant or think you may be pregnant, inform your doctor right away.
• It has been approved for the treatment of metastatic breast cancer and breast cancer.
• Fareston (toremifene citrate) is an estrogen agonist/antagonist that blocks estrogen from reaching cancer cells used to slow the growth of metastatic breast cancer (cancer that has spread from the original tumor).
• If the bleeding continues or is bothersome, check with your doctor right away.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Improve patient outcomes with diagnostic products and continuing education. To purchase short-term access, please sign in to your personal account above.

Toremifene citrate

Discuss the use of birth control, and the risks and benefits of this medication with your doctor. Because of the possible risk to the infant, breastfeeding is not recommended while using this drug. This medicine may increase your risk of having uterus problems, including endometrial cancer. Many drugs besides toremifene may affect the heart rhythm (QT prolongation), including amiodarone, granisetron, pimozide, procainamide, quinidine, sotalol, and macrolide antibiotics (such as erythromycin), among others.

For example, a SERM may act as an estrogen agonist in bone tissue, promoting bone density, while acting as an estrogen antagonist in breast tissue, preventing the growth of cancer cells. ERs modulators are compounds or substances that can interact with and modulate the activity of estrogen receptors (ERs). Estrogen receptors are proteins found in cells that are activated by the hormone estrogen. They play a crucial role in various physiological processes, including the development and maintenance of female reproductive organs, regulation of the menstrual cycle, and the growth and differentiation of breast tissue.

For full access to this pdf, sign in to an existing account, or purchase an annual subscription. A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions. Determine the effect of torimifene citrate on the HDL levels of hypogonadal men on TTh compared to both niacin and control groups. Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Adding plans allows you to compare formulary status to other drugs in the same class. There is no indication for use of FARESTON in pediatric patients.

Toremifene should not be prescribed to patients with congenital/acquired QT prolongation (long QT syndrome), uncorrected hypokalemia, or uncorrected hypomagnesemia. FARESTON is contraindicated in patients with known hypersensitivity to the drug. Toremifene has been shown to prolong the QTc interval in a dose- and concentration-related manner [see CLINICAL PHARMACOLOGY].

It is known that the combination of anti-estrogen drugs and warfarin anticoagulants together with Toremifene Citrate might lead to prolonged bleeding time. So Toremifene Citrate should be avoided in combination with the above drugs. Toremifene Citrate will reduce the renal excretion of calcium drugs, such as thiazide drugs, is the risk of increased hypercalcemia. MyTuftsMed is our new online patient portal that provides you with access to your medical information in one place.